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      Migraine is more than a headache
      
        
      Migraine is a complex neurological condition that can disrupt an individual¡¯s life. Migraine affects 1 in 4 households in the US.
      
        
      
          
      
            
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      Stages of a migraine attack
      
        
      Migraine can work through 4 stages, but not everyone who suffers from the condition goes through all the stages.
      
        
      
          
      
            
      
              
      Prodrome
      
            
      
            
      The time leading up to the headache, which can last from a few hours to a day or more. Common signs and symptoms of prodrome can include food cravings, mood changes, uncontrollable yawning, and difficulty concentrating.
      
          
      
          
      
            
      
              
      Aura
      
            
      
            
      A third of people with migraine experience an aura, a period marked by sensory symptoms such as visual disturbances (an aura can last from 5 minutes up to 1 hour).
      
          
      
          
      
            
      
              
      Headache
      
            
      
            
      A severe headache characterized by throbbing or pulsing pain on one or both sides of the head accompanied by other symptoms such as nausea and vomiting (this can last 4 to 72 hours).
      
          
      
          
      
            
      
              
      Postdrome
      
            
      
            
      This post-headache period is also known as the ¡°migraine hangover¡± or recovery period (this can last 24 to 48 hours). Postdrome symptoms may include fatigue, difficulty concentrating, and depressed mood.
      
          
      
        
      
        
      
          
      
            
      
            
      
          
      
        
      
        
      
          
      
            
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      Test your knowledge
      
        
      Family genetics can be a factor in your likelihood of experiencing migraine.
      
        
      Source: Yale Medicine
      
        
      
          
      
            
      
              
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      The correct answer is true!
      
            
      
          
      
        
      
        
      
          
      
            
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      Better understand some causes and treatment of migraine
      
        
      
          
      
            
      
              
      A potential root cause of migraine
      
            
      
            
      There are likely several factors that cause migraine. Many scientists now believe a potential root cause is related to a protein called calcitonin gene-related peptide (CGRP), a protein that is released by nerve cells. In migraine, CGRP is released and attaches to CGRP receptors, which may lead to dilation of blood vessels, inflammation, and increased pain signals to the brain.
      
          
      
          
      
            
      
              
      CGRP is released during migraine attacks
      
            
      
            
      
              
      
                
                  
                  
                  
                  Graphic depicting a normal amount of calcitonin gene-related peptide (CGRP) when not experiencing a migraine
                
              
      
              
      
                
                  
                  
                  
                  Graphic depicting a normal amount of calcitonin gene-related peptide (CGRP) when not experiencing a migraine
                
              
      
              
      Normal
      
              
      
                
                  
                  
                  
                  Graphic depicting an increased amount of calcitonin gene-related peptide (CGRP) released during a migraine
                
              
      
              
      
                
                  
                  
                  
                  Graphic depicting an increased amount of calcitonin gene-related peptide (CGRP) released during a migraine
                
              
      
              
      During Migraine
      
              
      For illustrative purposes only
      
            
      
          
      
          
      
            
      
              
      How blocking CGRP works
      
            
      
            
      CGRP blockers are one type of medication designed to treat migraine. They target and block pain signals thought to be linked to CGRP activity.
      
          
      
        
      
        
      
          
      
            
      
            
      
          
      
        
      
        
      
          
      
            
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      Find out about your treatment options.
      
              
      
                
                  
                  
                  
                  
                
              
      
              
      Talk to a doctor
      
              
      Prepare for your visit
      
            
      
            
      
              
                
                
                
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      Menopause & migraine:
      what to
      know
      
        
      Learn more about menopause
      
        
      
          
      
            
      
              
      Hormones can affect migraine
      
            
      
            
      
              
      
              
      Unpredictable changes in estrogen levels during perimenopause can change migraine frequency¡ªsome improve, while others worsen.
      
              
      Source: Menopause
      
            
      
          
      
          
      
            
      
              
      Migraine & perimenopause
      
            
      
            
      
              
      
              
      Migraine often worsens during perimenopause due to hormonal fluctuations.
      
              
      Source: American Migraine Foundation
      
            
      
          
      
          
      
            
      
              
      Migraine & postmenopause
      
            
      
            
      
              
      
              
      Migraine often improves postmenopause due to stabilization of hormones.
      
              
      Source: American Migraine Foundation
      
            
      
          
      
        
      
        
      
          
      
            
      
            
      
          
      
        
      
        
      
          
      
            
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      Frequently asked questions
      
        
      
          
      
            
      What is the current understanding of migraine?
      
            
      Migraine is more than a headache. As a complex neurological condition, migraine is a disorder that affects the brain and can cause intense pain on one or both sides of the head. Symptoms can include nausea, vomiting, sensitivity to light and/or sound, and poor concentration. A migraine attack can last 4 to 72 hours. There are approximately 40 million Americans living with migraine.
      
          
      
          
      
            
      What are common triggers for migraine?
      
            
      
              
      Many things can trigger a migraine attack, but they¡¯re not the same for everyone.
      Common triggers include:
      
              
        
                
      • Stress
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      • Certain foods
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      • Alcohol
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      • Skipping meals
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      • Sudden changes in weather/barometric pressure
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      • Hormonal changes in women around the time of their periods
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      • Changes in sleep patterns
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      • Over-medicating
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      This is not a complete list of migraine triggers. Beyond these triggers, having a family history of migraine and being female can also impact the likelihood of having migraine attacks.
      
            
      
          
      
          
      
            
      How does menopause affect migraine?
      
            
      Fluctuations in hormones during perimenopause, or the transition to menopause, can increase the frequency and severity of migraine attacks.
      
          
      
          
      
            
      How many people live with migraine?
      
            
      Migraine is one of the most common neurological diseases. Migraine affects 1 in 4 households in the US. There are approximately 40 million Americans living with migraine.
      
          
      
          
      
            
      Are there any recent developments that can help treat migraine?
      
            
      Over the last few years, there have been many developments in better understanding a potential root cause of migraine pain and the introduction of a new class of treatment. If your current migraine medication is not working for you, talk to your doctor about different treatments available today.
      
          
      
          
      
            
      How do I get rid of migraine attacks?
      
            
      There is no cure for migraine. However, there are treatment options. Since the severity and frequency of migraine attacks can differ from person to person, the way they¡¯re treated can vary. There are two main approaches to migraine care: stop migraine attacks after they start (acute) or prevent them before they start (preventive). Many people with migraine use both acute and preventive treatments. These types of treatments can come in the form of oral medications, nasal sprays, injections, or devices.
      
          
      
        
      
        
      
          
      
            
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 Suddenly into the blanks, into the black erasures, there stole the images which just now he had tried in vain to recall. All else was erased, and Norah filled the empty spaces. Her presence, voice and gesture and form pervaded his whole consciousness: there was room for nothing else. They loved each other, and to each other they constituted the sum of all that was real. There was nothing for it but to accept that, to go away together, and let all the unrealities of life, The Cedars, the salmon, the slippers, pass out of focus, be dissolved, disintegrated.... And yet, and yet he knew that he did not make the choice with his whole self. Deep down in him, the very foundation on which his character was built, was that hidden rock of his integrity, of his stern Puritanism, of the morality of which his religion was made. He was willing to blow that up, he searched for{305} the explosive that would shatter it, he hacked and hammered at it, as if in experiment to see if he had the power to shatter it. It could hardly be that his character was stronger than himself: that seemed a contradiction in terms.  Frank gave another swing of his hat and another cheer. The Doctor and Fred united their voices to his, and with a hearty shout all around, they concluded the ceremony connected with their arrival in Japan.  HOLLANDER AT DESHIMA WATCHING FOR A SHIP. HOLLANDER AT DESHIMA WATCHING FOR A SHIP. She struck a mock-sentimental attitude and murmured musically-- The sergeant's low order broke the platoon into column by file, Quinn rode toward its head with his blade drawn, and as he passed me he handed me his glass. "Here, you with no carbine, stay and watch that boat till I send for you. If there's firing, look sharp to see if any one there is hit, and who, and how hard. Watch the boat, nothing else." "Oh! she had letters from uncle to aunt Martha! He thinks she's wonderful!" And then, as Gregg took a leisurely stride towards the door, as though to investigate matters on his own, the Doctor caught hold of his sleeve. "Don't do that. Listen, first, to what I have to tell you. I rather fancy it will take the edge off your curiosity." Despite his vast wealth and the manner in which he was courted and flattered by society, Mr. Isaac Isidore had contrived to remain single. He had only one passion, and that was the making of money by ingenious schemes; in fact, had he not been a capitalist he would have made a wonderfully good novelist, as Lawrence often said. Mystery and intrigue were the very air he breathed, and for recreation he asked for nothing better than a romance by Gaboriau or Du Boisgobey. "I see, I see," the Countess replied. "If we could only scheme some plan----" They poured in thick and fast till the law intervened in the person of a posse of officials who represented the Sheriff of London, and then Hetty was permitted to pack up her belongings and those of the child and depart. Gilbert Lawrence received them with open arms. Bruce was there, pleased enough to get Hetty from the house where she had suffered so much. But there was a white despairing look that caused Hetty to forget her own troubles.  with teeth or a lizard with wings. No, it isn't either; I've just  Then a fat native lawyer began to speak, and silence fell on the crowd of three or four hundred listeners sitting behind the accused, as if they were in church. The monotonous voice went on and on, urging every plea. A tea-party in the afternoon at the yacht club. The ladies in smart dresses, the talk all of fashionable gossip¡ªhow far away from all I had been seeing. An European atmosphere, where a touch of local colour was only suggested by the native servants. The plague, the ruling terror when I was last in Bombay, was forgotten; the only subject now was the Jubilee, and the latest news from England arrived by that day's mail.  ¡°Let¡¯s see if Mr. Everdail won¡¯t listen to us about that, now.¡± "I'd have you know. Miss Widgeon, the papers don't magnify the matter. They don't make a fuss over nothing. They don't begin to tell all the truth. None o' them can. My brother was nearer dead than any man who ever lived. Nothing but the favor of God and Klegg grit pulled him through. It'd killed a whole house full o' Randy Widgeons or that Second Lieutenant. I remember Randy Widgeon turning pale and a'most fainting when he run a fish-hook in his finger. If it ain't nothing, why don't Randy Widgeon go down there a little while, with the rest o' the boys, and do his share?" "Who's in charge here?" he asked. The Alberts were shunted off without trouble. Albin, heaving a small sigh, fixed the details of his next job in his mind: quality control in a smelting process. It took him a few seconds to calm down and get ready, and then he headed for room six, where one Albert waited for him, trying to think only of the job ahead, and not at all of the party, of Dr. Haenlingen, of Johnny Dodd, of rebellion and war. She raised her head and looked him full in the face, her eyes like a bright challenge. Her face was quite sober when she spoke. "I'm in Psych, but it's more than morale, Johnny. We're¡ªalways thinking up new ways to keep the little Alberts in their place. Put it that way. Though nobody's really come up with an improvement on the original notion." She could not take much interest in Reuben's ambitions, indeed she only partly understood them. What did he want Boarzell for?¡ªit was so rough and dreary, she was sure nothing would grow there. She loved the farm, with the dear faces of the cows, and the horses, and the poultry, and even the pigs, but talk of crops and acres only bored her. Sometimes Reuben's enthusiasm would spill over, and sitting by the fire with her in the evening, he would enlarge on all he was going to do with Boarzell¡ªthis year, next year, ten years hence. Then she would nestle close to him, and murmur¡ª"Yes, dear" ... "yes, dear" ... "that will be glorious"¡ªwhile all the time she was thinking of his long lashes, his strong brown neck, the clear weight of his arm on her shoulder, and the kiss that would be hers when he took his pipe out of his mouth. Chapter 10 Let the banner of freedom float gaily on high,   HoMEmint006¾©Ïã
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